Is the PDF accessible?
There are many factors that make a PDF accessible. One of the most important features is called Tags. They are not visible. They are hidden information in the file that blind, low-vision, and dyslexic screen reader users rely on so they can hear the document.
If you have not already, configure Acrobat Pro for accessibility testing.
Then check if the PDF is already accessible.
If it is accessible, then you are done. If it has problems, we will remediate it using one of the journeys below.
Do you have the PDF's original source file?
This could be a Microsoft Office Document or an Adobe InDesign file.